Publications & Research Articles

 📘 Acetophenone-Substituted 5-(Methylamino)Benzotriazole Mannich Bases: Synthesis, Molecular Modeling, and Antioxidant Potential

D. Tatipakaa, R. Porapua, S. Telajalaa, M. Tummalapallia, and R. S. R. Dontireddya,

ISSN 1070-4280, Russian Journal of Organic Chemistry, 2025, Vol. 61, No. 12, pp. 2446–2456. © Pleiades Publishing, Ltd., 2025.

DOI: 10.1134/S107042802560158X

Acetophenone-Substituted 5-(Methylamino)Benzotriazole 

Mannich Bases: Synthesis, Molecular Modeling, 

and Antioxidant Potential

Summary:

This study reports the synthesis of novel acetophenone-substituted 5-(methylamino)benzotriazole Mannich bases and their structural characterization using standard spectroscopic techniques. Molecular modeling studies were performed to evaluate potential biological interactions, and the synthesized compounds were assessed for antioxidant activity. The findings highlight the potential of these derivatives as promising candidates for further pharmaceutical investigation.

📘 Euroleptics Targeting Metabotropic Glutamate Receptor (GRM5): Molecular Docking Studies of Substituted Quinolines

Raja P., Mounika T., Ravi Sankara Reddy D.

Journal of Cardiovascular Disease Research

2025, 16(5), 437–448

Summary:

This study explores the molecular docking analysis of substituted quinoline derivatives targeting the metabotropic glutamate receptor (GRM5). Computational modeling was performed to evaluate ligand–receptor interactions, binding affinity, and structural compatibility. The findings provide insights into the potential of quinoline-based compounds as neuroactive agents and support further investigation into their pharmacological applications.

📘 Molecular Docking Studies of Substituted Quinolines Against Angiotensin Converting Enzyme (ACE) as Potential Antihypertensive Agents

Raja P., Tarakeswara Rao P., Ravisankar Reddy D.

World Journal of Pharmaceutical Research

2025, 14(1), 1285–1295

DOI: https://doi.org/10.20959/wjpr20251-34989

Summary:

This study investigates substituted quinoline derivatives as potential antihypertensive agents targeting angiotensin converting enzyme (ACE). Molecular docking simulations were performed to evaluate binding affinity, interaction patterns, and stability within the ACE active site. The results suggest promising inhibitory potential and provide insights into structure–activity relationships for the development of novel cardiovascular therapeutics.